Essential Guide to IVF for Surrogates

Have you ever considered becoming a surrogate? It’s an amazing chance to help someone else create their family. This process usually involves in vitro fertilization (IVF), a medical way to get pregnant for surrogacy. If you’re thinking about being a gestational surrogate, understanding IVF is important to help you prepare for your surrogacy journey. This guide will explain IVF, what you’ll do as a surrogate, and some helpful tips for taking IVF medications.

Understanding IVF in Surrogacy

IVF is a form of assisted reproduction where doctors use eggs and sperm, either from the intended parents (the couple trying to have a baby) or a donor, to create embryos in a lab setting. Then, they place the resulting embryos (tiny fertilized eggs) into the surrogate’s uterus with the hope that one will implant and grow into a healthy baby. The goal is to achieve a successful pregnancy, and as a surrogate, you play a vital role in this process.

The Surrogate’s Role in the IVF Cycle

As a surrogate, the surrogacy process starts long before the embryo transfer. First, you’ll undergo comprehensive medical and psychological evaluations to ensure you’re a suitable candidate for surrogacy. Once you receive medical clearance, you’ll take specific medications that help create the ideal environment in your uterus for the embryos. These medications might include estrogen and progesterone, which are crucial in supporting the early stages of pregnancy.

Medications in the IVF Cycle

During the IVF cycle, surrogates are typically required to take several types of medications:

  • Hormonal Supplements (Estrogen and Progesterone): These hormones help prepare the lining of your uterus to receive and support the embryos. They are usually administered through pills, patches, or injections.
  • GnRH Agonists (e.g., Lupron): This medication prevents premature ovulation by regulating hormone levels, ensuring that your cycle synchronizes with the embryo transfer schedule. It’s typically administered via injection.
  • Antibiotics: Often prescribed to prevent any potential infection that could affect the pregnancy.
  • Prenatal Vitamins: These supplements ensure you have all the necessary nutrients to support a healthy pregnancy environment.

Side effects of IVF medications

It’s important to be aware of the potential risks and side effects associated with IVF medications before starting the surrogacy process. These medications are designed to prepare your body for embryo implantation but can sometimes lead to uncomfortable or even challenging side effects, including:

  • Bloating and discomfort
  • Mood swings and emotional variability
  • Headaches
  • Nausea
  • Injection site reactions such as pain, redness, or swelling

These side effects vary in intensity and duration from person to person, but they are generally temporary. The fertility clinic will guide you through these risks and help manage any side effects that occur.

Tips for Administering Injections

Many of the medications required during the IVF process are administered through injections, which can seem daunting at first. Here are some tips to help you manage injections:

  • Get Organized: Before you begin your medication regime, organize your supplies. Make sure you have everything you need, including alcohol wipes, sterile needles, and proper disposal containers.
  • Stay Relaxed: Find a comfortable, quiet place to administer injections. Being relaxed can help reduce discomfort.
  • Rotate Sites: To avoid discomfort and bruising, rotate the injection sites. Common areas include the abdomen, upper thighs, and upper arms.
  • Cold Packs: Applying a cold pack to the injection site before and after the injection can help numb the area and reduce swelling.
  • Consistency is Key: It’s crucial to take your medication at the same time each day. Consistency helps maintain the necessary hormone levels in your body to support a successful embryo implantation.

Natural IVF Cycles for Surrogates

Now, you may be wondering, “Do I HAVE to take medications as a surrogate?” The answer is, “It depends.” Some doctors actually prefer to use a natural IVF cycle when it comes to surrogacy. In natural IVF cycles, the process is simplified by timing the transfer of a frozen embryo with the surrogate’s natural menstrual cycle. This approach takes advantage of the surrogate’s natural fertility without the use of supplemental hormones.

How natural IVF cycles work in surrogacy

  • Cycle Monitoring: The surrogate’s menstrual cycle is monitored to track the timing of her natural ovulation. This monitoring usually involves regular ultrasound scans and hormone level tests.
  • Embryo Transfer Preparation: The objective is to time the transfer of a previously frozen embryo to coincide with the natural receptivity of the surrogate’s uterus immediately following her ovulation.
  • Embryo Transfer: A frozen embryo, created from the egg and sperm of the intended parents or donors, is thawed and transferred into the surrogate’s uterus at an optimal time in her cycle.

Benefits of natural IVF for surrogates

  • No medications for stimulation: The surrogate does not need to take medications except for perhaps birth control pills, avoiding the discomfort and side effects associated with stimulation medications.
  • Leveraging natural fertility: Since surrogates typically have a history of successful pregnancies, timing the embryo transfer with their natural cycle can be effective without the need for additional hormonal support. This natural approach often suits the surrogate’s body well, potentially leading to a more comfortable and less medically involved process.
  • Simplified Protocol: The treatment protocol is less complex because it avoids stimulation drugs. It focuses primarily on monitoring and preparing for a timely embryo transfer.


  • Dependency on Natural Cycle Timing: Success depends on the precise tracking and timing of the surrogate’s natural ovulation, which can be less predictable.
  • Potential for Cancellation: If the timing of the natural cycle does not align optimally with the embryo transfer or if there are issues with the surrogate’s uterine lining, the cycle might be canceled.
  • Variable Success Rates: While this approach eliminates the risks associated with hormonal stimulation, success rates per cycle may vary, influenced by the quality of the surrogate’s uterine lining.

Natural IVF cycles using frozen embryos can be a good choice for surrogates and intended parents who prefer a less medically intensive approach. It’s important for all parties involved to discuss this option with their fertility specialists to understand the benefits and limitations, ensuring it aligns with their expectations and increases the likelihood of a successful surrogacy journey.

Managing expectations

It’s important to have realistic expectations about the success rates of IVF. Not every transfer results in pregnancy, and it may take more than one attempt to achieve a successful pregnancy. Success rates can vary based on many factors, including the age of the eggs used, the quality of the sperm, and your overall health. Your fertility clinic will discuss these factors with you to set realistic expectations for the IVF cycle.

What If It Doesn’t Work?

Facing a failed transfer can be emotionally challenging for everyone involved. Here’s what typically happens if a transfer doesn’t result in pregnancy:

  • Evaluation and feedback: Your medical team will review the cycle closely to understand any factors that might have contributed to the lack of success. This review includes looking at the surrogate’s response to medications, the embryo development, and the transfer process itself.
  • Adjusting the treatment plan: Based on the insights gained from the review, doctors might adjust the treatment plan. This could involve changing medications, altering dosages, or adjusting the timing of the embryo transfer.
  • Support and counseling: Emotional support is crucial. Many surrogacy programs offer access to counseling services to help surrogates and intended parents manage their feelings and prepare for the next steps.
  • Preparing for another cycle: If everyone agrees to proceed, preparations for another IVF cycle might begin. This could be with new embryos, if available, or through another egg retrieval process.

Understanding that multiple attempts may be necessary helps set a realistic mindset and prepares you emotionally for all possible outcomes.

Ready to start your surrogacy journey?

Understanding every aspect of the IVF cycle is essential for anyone considering becoming a surrogate. By educating yourself, you not only prepare for the physical demands of surrogacy but also empower yourself to make informed decisions throughout the process. Remember, you are not alone in this journey. There are resources and people ready to support you every step of the way.

If you’re ready to explore this life-changing opportunity, reach out to Fairfax Surrogacy today. We’re here to guide you through every step and help you begin your journey as a surrogate.